Tuesday, 18 February 2025

Understanding testosterone

As we know blocking testosterone production halts tumour growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced. This never made that much sense....Now it seems we have an explanation: 

"The researchers found that prostate cancer cells are hardwired with a system that allows them to proliferate when the levels of testosterone are very low. But when hormone levels are elevated to resemble those present in the normal prostate, the cancer cells differentiate....It turned out to be rather simple. When androgen levels are low, the androgen receptor is encouraged to “go solo” in the cell. In doing so, it activates the pathways that cause cancer cells to grow and spread. However, as androgens rise, the androgen receptors are forced to “hang out as a couple,” creating a form of the receptor that halts tumor growth. Nature has designed a system where low doses of hormones stimulate cancer cell proliferation and high doses cause differentiation and suppress growth, enabling the same hormone to perform diverse functions."

Here's the research article: https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer

Here's also Chris Woollams at Canceractive writing in 2020 about hormone treatment (before this recent discovery). His article is an interesting look at current practice and a possibly different approach to hormones: https://www.canceractive.com/article/the-reality-of-lowered-testosterone-and-higher-oestrogen-in-men-counters-orthodox-theories-of-prostate-cancer He concludes rather grimly: "It all really seems a bit of a mess. Low Testosterone makes matters worse and standard treatment is to cut testosterone! Blood fat levels make matters worse, and standard treatment raises them! Anti-oestrogens seem to do a good job and no oncologist thinks to explore an anti-oestrogen, or indole 3 carbinol, or melatonin?. Meanwhile the number of prostate deaths climb, and recurrence is a major factor. As a friend of mine with a prostate cancer a decade ago said 'there doesn't seem to be best practice in prostate cancer'. He could well be right."

We still have a way to go - the latest research is very useful in helping us understand.

Monday, 10 February 2025

Sunday, 9 February 2025

Inspire2Live

What a great name for an organisation, Inspire2Live - I joined them as a patient advocate several years ago now - we are some 100 patient advocates from dozens of countries around the world. The group meets online every week and in person at conferences - sadly I've been only on the edges of this group as meeting times are a challenge. However it is great to see this group making real tangible changes - see Peter Kapitein at a recent conference - he was the guy that started this all off: https://www.youtube.com/watch?v=tkHeAJ9jUVo

Check out Inspire2Live at: https://inspire2live.org/

And here are the advocates from around the World: https://inspire2live.org/about-us/patient-advocacy/meet-our-patient-advocates/

Friday, 10 January 2025

Find out more about peer-to-peer support groups

As regular blog readers will know I used to work for Yes to Life and help establish their cancer support groups in real life and online. To find out more about these there is an excellent new radio show with Sara Spinks, the current Co-ordinator for the Yes to Life programme of Wigwam Support Groups. She is an ardent advocate for the many benefits of group work including looking into the deeper questions of life, or simply for mutual support and learning.

All the groups are consistently appreciated by members on a wide variety of levels. During the interview, two Yes to Life Wigwam Group members will also describe what keeps them coming back for more.

Find out more about Yes to Life’s Wigwam Cancer Support Groups via the links below:

Check thepodcast out at: https://yestolife.org.uk/radio_shows/groups-healing-power-of-meeting/

See also my blog on what can make the biggest difference to our healing: https://myunexpectedguide.blogspot.com/2021/03/what-can-make-biggest-difference-to-our.html

And about building a community of Wigwam groups: https://myunexpectedguide.blogspot.com/2021/05/building-community-of-peer-led-support.html

Feeling creative? Could you help with our next cancer and art magazine?

Flourish Magazine is a joint venture between integrative cancer care charity Yes to Life and creative health charity Artlift, funded by National Lottery Awards for All, Arts Council, 
Gloucestershire Health and Care NHS Foundation Trust and many others. I helped establish this magazine to be a space explore the benefits of an integrative and creative approach to living with cancer.

It features a range of creative responses, expert information and interviews in each themed edition that offer support and represent the diversity of the cancer community.

Can you help? We are after content, paintings, photos, poems and more for our next issue with the theme 'Mind'. To get involved check out our latest issue on the 'body' with a look at tattoos, sex and more - back pages tell how to get involved.

See our previous five issues at: https://yestolife.org.uk/flourish-magazine/

Monday, 23 December 2024

An answer to rising costs and chronic illness

Our health services are at and in many places beyond breaking point. While we can hope the new government will restore some of the funding it is clear that health needs and costs are continuing to rise. In the next 15 years those living with a major illness are forecast to rise by 2.5 million to 9.1 million (i). 

So what can tackle rising costs and massively rising ill-health?


In this blog I will look at part of the answer that is already being tried with some wonderful results in terms of cutting costs and improved health outcomes. Perhaps the best articulation of the approach is the book “The Community Cure. Transforming Health Outcomes Together” by James Maskell (ii).


Maskell notes that we are facing a profound and worsening epidemic of loneliness and this is exacerbating chronic disease. He cites many examples of isolation as a social determinant of health including a 2017 questionnaire-based study where Medicare recipients older than 50, who ultimately were defined as “lonely”, experienced death rates 31% higher than their peers who did not self-identify as socially isolated. 


This research is not new - there is loads showing a range of health conditions associated with loneliness and social isolation, including heart disease and stroke, type 2 diabetes, rheumatoid arthritis and cancer. Even recovery following heart surgery can be compromised by isolation.


In the book Maskell argues that to counter this we should turn to group medical appointments; a supportive community provides the space to help develop healthy behaviors - a key to reversing chronic illness. This also can ‘shift our collective focus to prevention and root cause resolution’.


The book looks at the many ways group medical visits are being used - and the powerful evidence of them as a treatment for the loneliness epidemic. 


One of the examples Maskell looks at is the work of Dr Jeffrey Geller’s. This doctor found that patients who lacked support systems accessed medical care at a greater rate, so he decided to create a support system by forming group visits with a cohort of diabetes patients. Geller notes “People’s loneliness improved, people’s depression improved, they lost weight … blood pressure reduced by 5-10 points, and hemoglobin A1C also reduced”. 


I’ve personally seen the benefits of a group of people coming together and supporting each other - the peer-led Wigwam cancer support groups are a great example. See my blog post on this; ‘What makes the biggest difference to our healing’: https://yestolife.org.uk/what-can-make-the-biggest-difference-to-our-healing/


I’ve also seen benefits accruing from groups like the Cancer Exercise group at Stratford Park Leisure Centre supported by Stroud District Council. I believe there is huge potential for more of this intentional coming together.


One obvious possibility might be the one-off prehab talk now being run by local cancer services. Could that be expanded into a series of group activities looking more at nutrition, exercise, sleep, stress and more? This of course doesn’t mean there will not be some individual appointments but the bulk of issues can be raised in the groups. One of the findings into researching this approach showed that folk didn’t have time to raise key stuff in an individual appointment but there was time in the groups. Furthermore some patients were more shy to raise issues and found it useful that others in the group asked those questions.


‘Confidentiality’ I hear some folks cry. Yes any group work needs to consider this issue, Maskell has a section in his book on this, but it seems clear to me that group visits don’t destroy a patients privacy. What they do offer is a safe space for folks to be vulnerable and this can be a key part in healing.


Maskell writes: “We need more connection, more empathy, more social connectivity, and less loneliness, less social isolation. In a culture and society that emphases and prioritises privacy, we’ve inadvertently contributing to the very epidemic we’re trying to solve."


Maskell provides many resources for those interested in starting their own group visits, primarily through his website, “Evolution of Medicine.” I also know there are many skilled practitioners within our NHS who no doubt already have the skills to develop this approach.


With families and communities no longer meeting our needs we have seen what Maskell calls ‘total commodification’. We need ever more money to pay for counselling, babysitters, care and more - these were once shared by the community itself. It seems we now only look to the market or government for solutions. It’s time for a refocus…..group appointments are a way whose time has come. It would be great to see if there are opportunities to expand these ideas in Gloucestershire?


Update 10.01.25: Just heard this useful podcast re James Maskell: https://creators.spotify.com/pod/show/robin-daly6/episodes/James-Maskell--Diana-Lindsay-e2sjofc


There are many other podcasts with James Maskell on his website and online. Here are a couple:

Dr Chatterjee interview: https://drchatterjee.com/the-secret-to-radically-improving-your-health-that-nobodys-talking-about-with-james-maskell/


Oncologist Nasha Winter's interview: https://www.youtube.com/watch?v=HJanBC_xi3o&t=1s


Here are a couple more of my blogs looking at the impact of social support and community:


See blog about building a community of Wigwam Cancer Support Groups:

https://myunexpectedguide.blogspot.com/2021/05/building-community-of-peer-led-support.html


See blog on social prescribing and anti-social prescribing: 

https://myunexpectedguide.blogspot.com/2019/12/social-prescribing-for-people-living.html



Notes:

  1. https://www.health.org.uk/reports-and-analysis/reports/health-in-2040-projected-patterns-of-illness-in-england
  2. https://thecommunitycure.com/getyourcopy

Sunday, 22 December 2024

Reiki proven to provide symptom relief

Research out last month showed that energy healing, in the form of Reiki therapy, can provide significant symptom relief in cancer patients receiving standard treatments. In this study published in the Journal of Pain and Symptom Management, they found that patients given Reiki during chemotherapy experienced a clinically significant improvement in nausea, pain, fatigue anxiety.

As someone who took a basic reiki course many years ago I don't doubt this - while my brain can hardly compute how it could work I have seen first hand the evidence of improved wellbeing when reiki has been used. I also used it for myself when I was going through radiotherapy and do return to it when it feels the right approach.

Indeed this is not the only research supporting energy healing - a great book I read a couple of years ago is David Hamilton's 'Why Woo-Woo Works, The Surprising Science Behind Meditation, Reiki, Crystals and Other Alternative Practices'. There is a whole chapter on Reiki including research on using it with cancer patients to lessen the impact of treatments.

Understanding testosterone

As we know blocking testosterone production halts tumour growth in early disease, while elevating the hormone can delay disease progression ...